AstraZeneca has said it will reduce its U.S. sales force by about 1,150 positions.

The company said the job cuts were not included in any “previously announced efficiencies to its U.S. business.”

AstraZeneca which is based in London and has its U.S. headquarters in Wilmington, Del., said impact of the work force reductions will vary by geography and selling teams. All decisions will be finalized by early February.